Formulation of a Synergistic Herbal Blend of Green Tea (Camelia sinensis) and Traditional Spices for Immune Support and Anxiety Relief

Ananta Ardyansyah, Dika Putra Wijaya, Danar Danar, Tsalis Jauza Nareswari, Anggun Frista Utami, Annisaa Annisaa, Diana Nadhifah, Lely Fitrianingrum

Abstract


COVID-19 not only brings problems to physical health but also mental health, such as anxiety. Excessive anxiety is very dangerous because it can reduce the number of white blood cells in the bloodstream. Excessive anxiety also triggers the production of excess cortisol which interferes with the immune system. This could be overcome by the combination of tea which has a relaxing effect with several immunomodulatory herbs. Green tea (Camellia sinensis) has been shown to have the effect of reducing one's anxiety and improving one's psychological health. The tea is combined with other spices, namely (Zingiber officinale), turmeric (Curcuma domestica Val), and cinnamon (Cinnamomum burmannii). This study was conducted to find out that the combination formed has met safety standards, so it can be used as an immunity-boosting drink during a pandemic. Standardization includes testing for moisture content, ash content, and organoleptic tests. The results obtained were the water content of herbal tea was as much as 6.26%, while the ash content of the tea was 5.74%. The water content and ash content had met the standards of the Ministry of Health regarding the preparation of herbal medicines. The organoleptic test performed showed that the formulation obtained was dominated by the taste of ginger, the color of turmeric, and the smell of cinnamon.


Keywords


Anxiety; immunity booster; herbal tea formulation; traditional herb; green tea

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References


Akila, B., & Vijayalakshmi. (2018). Development and evaluation of functional property of guava leaf based herbal tea. https://api.semanticscholar.org/CorpusID:208264912

Allen, M. J., & Sharma, S. (2018). Physiology, Adrenocorticotropic Hormone (ACTH). StatPearls. http://www.ncbi.nlm.nih.gov/pubmed/29763207

Anindyajati, G., Wiguna, T., Murtani, B. J., Christian, H., Wigantara, N. A., Putra, A. A., Hanafi, E., Minayati, K., Ismail, R. I., Kaligis, F., Savitri, A. I., Uiterwaal, C. S. P. M., & Diatri, H. (2021). Anxiety and Its Associated Factors During the Initial Phase of the COVID-19 Pandemic in Indonesia. Frontiers in Psychiatry, 12. https://api.semanticscholar.org/CorpusID:232163086

Ariviani S dan Ishartani D. (2009). Formulasi Teh Herba Manis: Organoleptik, Antioksidan dan Total Kalori (Formulation of Sweet Herb Tea: Organoleptic, Antioxidant and Total Calori). Jurnal Teknologi Hasil Pertanian, II(2), 78–86.

Atmadja, T. F. A., & Yunianto, A. E. (2019). Formulasi minuman fungsional teh meniran (Phyllanthus niruri) tinggi antioksidan. AcTion: Aceh Nutrition Journal, 4(2), 142. https://doi.org/10.30867/action.v4i2.185

Bai, X., He, Y., Quan, B., Xia, T., Zhang, X., Wang, Y., Zheng, Y., & Wang, M. (2022). Physicochemical properties, structure, and ameliorative effects of insoluble dietary fiber from tea on slow transit constipation. Food Chemistry: X, 14, 100340. https://doi.org/https://doi.org/10.1016/j.fochx.2022.100340

Baur, F. J., & Ensminger, L. G. (1977). The Association of Official Analytical Chemists (AOAC). Journal of the American Oil Chemists’ Society, 54(4), 171–172. https://doi.org/10.1007/BF02670789

Britany, M. N., & Sumarni, L. (2020). Pembuatan Teh Herbal Dari Daun Kelor Untuk Meningkatkan Daya Tahan Tubuh Selama Pandemi Covid-19 Di Kecamatan Limo. Prosiding Seminar Nasional Pengabdian Masyarakat LPPM UMJ, 1–6. http://jurnal.umj.ac.id/index.php/semnaskat

Castillo, L., Baltodano, E., Ramirez, N., Vargas, R., & Hanley, G. (2020). Design of Experiments Assessment for the Determination of Moisture Content in Five Herbal Raw Materials Contained in Tea Products. Borneo Journal of Pharmacy, 3(1), 22–35. https://doi.org/10.33084/bjop.v3i1.1236

Chatterjee, S., Chatterjee, A., & Bandyopadhyay, S. K. (2016). L-theanine: A prospective natural medicine. International Journal of Pharmaceutical Sciences Review and Research, 41(2), 95–103.

Departemen Kesehatan RI. (2000). Parameter Standar Umum Ekstrak Tanaman Obat. In Departemen Kesehatan RI (1st ed., Vol. 1). DirektorJenderal Pengawasan Obat dan Makanan.

Ehoche, E. E., Patel, P., Madu, C., & Adejoh, J. (2021). Formulation, Organoleptic Evaluation, and Acceptability of Various Teas from Underutilized Nutritious Herbs Compared with Marketed Chinese and Yellow Lipton Tea. Borneo Journal of Pharmacy, 4(1), 51–56. https://doi.org/10.33084/bjop.v4i1.1817

Food and Agriculture Organization. (2003). Food Energy - Methods of Analysis and Conversion Factors. In Report of a Technical Workshop. https://www.fao.org/uploads/media/FAO_2003_Food_Energy_02.pdf

Gallagher, C. E., Watt, M. C., Weaver, A. D., & Murphy, K. A. (2017). “I fear, therefore, I shop!” exploring anxiety sensitivity in relation to compulsive buying. Personality and Individual Differences, 104, 37–42. https://doi.org/10.1016/j.paid.2016.07.023

Ghasemzadeh, A., Jaafar, H. Z. E., & Rahmat, A. (2016). Variation of the Phytochemical Constituents and Antioxidant Activities of Zingiber officinale var. rubrum Theilade Associated with Different Drying Methods and Polyphenol Oxidase Activity. Molecules (Basel, Switzerland), 21(6). https://doi.org/10.3390/molecules21060780

Gilbert, C. (2014). The Effect of Tea and its Constituent L-Theanine on Anxiety: A Review of the Literature. In Igarss 2014 (Issue 1). California Polytechnic State University.

Gombart, A. F., Pierre, A., & Maggini, S. (2020). A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients, 12(1). https://doi.org/10.3390/nu12010236

Goodman, K. (2022). Health Anxiety: What It is and How to Beat I. Anxiety and Depression Association of America. https://adaa.org/learn-from-us/from-the-experts/blog-posts/consumer/health-anxiety-what-it-and-how-beat-it#:~:text=Since it is possible to,anxiety including health related anxiety.

Hidayat, H. N., & Insafitri. (2021). PROXIMATE ANALYSIS OF Thalassia hemprichii AND Galaxaura rugosa IN BANGKALAN DISTRICT. Jurnal Turnojoyo Juvenil, 2(4), 307–317.

Hosseini, F. S., Sharifi, N., & Jamali, S. (2020). Correlation Anxiety , Stress , and Depression with Perceived Social Support Among the Elderly : A Cross-Sectional Study in Iran Content courtesy of Springer Nature , terms of use apply . Rights reserved . Content courtesy of Springer Nature , terms of use.

Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S. S., Samouda, H., La Frano, M. R., & Bohn, T. (2020). Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients, 12(6). https://doi.org/10.3390/nu12061562

ISO 11287 Green Tea Definition and Basic Requirements (2011). https://www.iso.org/obp/ui/en/#iso:std:iso:11287:ed-1:v1:en

Kusumawati, N., Bahar, A., Setiarso, P., Muslim, S., & Auliya, A. R. S. (2021). GINGER AND TEMULAWAK BASED HERBAL TEA AS POTENTIAL FUNCTIONAL DRINK PRODUCTS IN THE ERA OF COVID-19. Rasayan Journal of Chemistry. https://api.semanticscholar.org/CorpusID:239257856

LaMarco, K., & Post, K. (2019). Stress and the immune system. Science, 364(6443), 848. https://doi.org/10.1126/science.364.6443.846-s

Lengvenyte, A., Strumila, R., Belzeaux, R., Aouizerate, B., Dubertret, C., Haffen, E., Llorca, P. M., Roux, P., Polosan, M., Schwan, R., Walter, M., D’amato, T., Januel, D., Leboyer, M., Bellivier, F., Étain, B., Navickas, A., Olie?, E., & Courtet, P. (2022). Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort. Brain, Behavior, and Immunity, 108, 176–187. https://api.semanticscholar.org/CorpusID:254293617

Li, P., Yin, Y. L., Li, D., Kim, W. S., & Wu, G. (2007). Amino acids and immune function. British Journal of Nutrition, 98(2), 237–252. https://doi.org/10.1017/S000711450769936X

Lim, J. (2011). Hedonic scaling: A review of methods and theory. Food Quality and Preference, 22(8), 733–747. https://doi.org/10.1016/j.foodqual.2011.05.008

Mao, Q.-Q. Q., Xu, X.-Y. Y., Cao, S.-Y. Y., Gan, R.-Y. Y., Corke, H., Beta, T., & Li, H.-B. Bin. (2019). Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe). Foods, 8(6), 1–21. https://doi.org/10.3390/foods8060185

National Research Council. (1990). Diet and health: implications for reducing chronic disease risk. Choice Reviews Online, 27(06), 27-3332-27–3332. https://doi.org/10.5860/CHOICE.27-3332

Nobre, A. C., Rao, A., & Owen, G. N. (2008). L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 17 Suppl 1, 167–168.

Pratiwi, D., Sidoretno, W. M., & Aisah, N. (2021). The Combination of Turmeric (Curcuma domestica) Rhizome Extract and Collagen in A Serum Formulation as an Antioxidant. Borneo Journal of Pharmacy, 4(1), 36–42. https://doi.org/10.33084/bjop.v4i1.1578

Pratiwi, Y. S., Sanjaya, Y. A., Rahmawati, R., Putri, L. A. H. H., & Syari, R. M. (2024). The Effect of Herbal Tea Formulation Made of Mangosteen Pericarp (Garcinia mangostana), Cinnamon (Cinnamon verum), and Clove (Syzygium aromaticum) on Panelist Acceptance Level. Amerta Nutrition, 8(1), 1–7. https://doi.org/10.20473/amnt.v8i1.2024.1-7

Priyadarshini, S., & Aich, P. (2012). Effects of Psychological Stress on Innate Immunity and Metabolism in Humans: A Systematic Analysis. PLoS ONE, 7(9). https://doi.org/10.1371/journal.pone.0043232

Rizkianto, W., Kunarto, B., & Pratiwi, E. (n.d.). Teabag formulation black tea based on black tea Bohea grade (Camellia sinensis L.) with peppermint leaves (Mentha piperita L.) on antioxidant activity.

Salari, N., Hosseinian-Far, A., Jalali, R., Vaisi-Raygani, A., Rasoulpoor, S., Mohammadi, M., Rasoulpoor, S., & Khaledi-Paveh, B. (2020). Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: A systematic review and meta-analysis. Globalization and Health, 16(1), 1–11. https://doi.org/10.1186/s12992-020-00589-w

Salim, S. (2016). Oxidative stress: a potential link between emotional wellbeing and immune response. Current Opinion in Pharmacology, 29, 70–76. https://doi.org/10.1016/j.coph.2016.06.006

Santabárbara, J., Bueno-Notivol, J., Lipnicki, D. M., Olaya, B., Pérez-Moreno, M., Gracia-García, P., Idoiaga-Mondragon, N., & Ozamiz-Etxebarria, N. (2021). Prevalence of anxiety in health care professionals during the COVID-19 pandemic: A rapid systematic review (on published articles in Medline) with meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 107, 110244. https://doi.org/https://doi.org/10.1016/j.pnpbp.2021.110244

Santabárbara, J., Lasheras, I., Lipnicki, D. M., Bueno-Notivol, J., Pérez-Moreno, M., López-Antón, R., De la Cámara, C., Lobo, A., & Gracia-García, P. (2021). Prevalence of anxiety in the COVID-19 pandemic: An updated meta-analysis of community-based studies. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 109, 110207. https://doi.org/https://doi.org/10.1016/j.pnpbp.2020.110207

Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130(4), 601–630. https://doi.org/10.1037/0033-2909.130.4.601

Sengupta, S., Bhattacharyya, D., Kasle, G., Karmakar, S., Sahu, O., Ganguly, A., Addya, S., & Das Sarma, J. (2021). Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan ?-Coronaviruses. Frontiers in Cellular and Infection Microbiology, 11, 729622. https://doi.org/10.3389/fcimb.2021.729622

Shafiee, M., Tayefi, M., Hassanian, S. M., Ghaneifar, Z., Parizadeh, M. R., Avan, A., Rahmani, F., Khorasanchi, Z., Azarpajouh, M. R., Safarian, H., Moohebati, M., Heidari-Bakavoli, A., Esmaeili, H., Nematy, M., Safarian, M., Ebrahimi, M., Ferns, G. A., Mokhber, N., & Ghayour-Mobarhan, M. (2017). Depression and anxiety symptoms are associated with white blood cell count and red cell distribution width: A sex-stratified analysis in a population-based study. Psychoneuroendocrinology, 84, 101–108. https://api.semanticscholar.org/CorpusID:13795607

Singh, S. A., Patel, Y., Patel, S., Ajay, M., & Chauhan, V. (2023). Formulation, evaluation, and antimicrobial study of immune-boosting herbal tea. Pharmaspire. https://api.semanticscholar.org/CorpusID:266365786

Sinija, V. R., & Mishra, H. N. (2008). Green tea: Health benefits. Journal of Nutritional & Environmental Medicine, 17(4), 232–242. https://doi.org/10.1080/13590840802518785

Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417–1435. https://doi.org/10.3390/nu5041417

Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular Medicine Reports, 3(6), 895–901. https://doi.org/10.3892/mmr.2010.377

Stefanache, A., Lungu, I.-I., Butnariu, I.-A., Calin, G., Gutu, C., Marcu, C., Grierosu, C., Bogdan Goroftei, E. R., Duceac, L.-D., Dabija, M. G., Popa, F., & Damir, D. (2023). Understanding How Minerals Contribute to Optimal Immune Function. Journal of Immunology Research, 2023, 3355733. https://doi.org/10.1155/2023/3355733

Stone, H., & Sidel, J. L. (2004). Sensory Evaluation Practices. In H. Stone & J. L. B. T.-S. E. P. (Third E. Sidel (Eds.), Food Science and Technology. Elsevier. https://doi.org/10.1016/B978-0-12-672690-9.X5000-8

Suhesti, I., Kustini, H., & Antari, E. D. (2021). Penggunaan Teh Serai Jahe Sebagai Penambah Daya Tahan Tubuh Menggunakan Daun Stevia Sebagai Pemanis Alami. RESWARA: Jurnal Pengabdian Kepada Masyarakat, 2(2), 325–330. https://doi.org/10.46576/rjpkm.v2i2.1155

Syah, A. N. A., & Sumangat, D. (2009). L-Theanin: Asam Amino Unik dari Teh Hijau. Prosiding Seminar Nasional Teknologi Inovatif Pascapanen Untuk Pengembangan Industri Berbasis Pertanian, 06, 679–687.

Vuong, Q. V, Bowyer, M. C., & Roach, P. D. (2011). L-Theanine: properties, synthesis and isolation from tea. Journal of the Science of Food and Agriculture, 91(11), 1931–1939. https://doi.org/10.1002/jsfa.4373

Wijayanti, A. (2022). A Formulasi ‘Zilang Tea” Teh Herbal Peningkat Imunitas Tubuh Berbahan Jahe Merah (Zingiber officinale var. Rubrum) dan Bunga Telang (Clitoria ternatea). Jurnal Ilmu Kesehatan Bhakti Setya Medika, 7(1), 20–25. https://doi.org/10.56727/bsm.v7i1.80

Williams, J. L., Everett, J. M., D’Cunha, N. M., Sergi, D., Georgousopoulou, E. N., Keegan, R. J., McKune, A. J., Mellor, D. D., Anstice, N., & Naumovski, N. (2020). The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods for Human Nutrition, 75(1), 12–23. https://doi.org/10.1007/s11130-019-00771-5

Windarwati, H. D., Lestari, R., Poeranto, S., Ati, N. A. L., Kusumawati, M. W., Ilmy, S. K., Sulaksono, A. D., Fitriyah, E. T., & Oktaviana, W. (2023). Anxiety, Depression, and Associated Factors among General Population in Indonesia during COVID-19 Pandemic: A Cross-Sectional Survey. Journal of Caring Sciences, 12, 144–154. https://api.semanticscholar.org/CorpusID:264140054

Xiong, J., Lipsitz, O., Nasri, F., Lui, L. M. W., Gill, H., Phan, L., Chen-Li, D., Iacobucci, M., Ho, R., Majeed, A., & McIntyre, R. S. (2020). Impact of COVID-19 pandemic on mental health in the general population: A systematic review. Journal of Affective Disorders, 277, 55–64. https://doi.org/https://doi.org/10.1016/j.jad.2020.08.001




DOI: https://doi.org/10.14421/biomedich.2025.142.1561-1568

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Copyright (c) 2026 Ananta Ardyansyah, Dika Putra Wijaya, Danar, Tsalis Jauza Nareswari, Anggun Frista Utami, Annisaa, Diana Nadhifah, Lely Fitrianingrum



Biology, Medicine, & Natural Product Chemistry
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