Compliance Level of Textual Therapeutic Usage of Kshirakakoli Containing Formulations with a Serial Ethnomedicinal Survey and Modern System of Medicine

Gunpreet Kaur, Vikas Gupta, Ravinder Sharma, Sanjiv Kumar, R G Singhal, Ranjit Singh, Parveen Bansal


Fritillaria roylei (Kshirakakoli) is a primal plant used in ancient times. But nowadays, due to biotic and abiotic stress the plant has entered in the list of threatened medicinal plant. In ancient texts effective uses of formulations containing kshirakakoli are well mentioned but the information is not written in simple language due to which the therapeutic value of the plant is not well understood by scientific fraternity. So, there is a major need to perform ethno medicinal survey for the formulations containing kshirakakoli and compare their therapeutic uses as mentioned in text with the modern system of medicine. In this study, a field survey was performed in 4 states i.e., Uttar Pradesh, Uttrakhand, Punjab and Himachal Pradesh where the conversation regarding usage of this plant or formulation was done with 24 local medical practitioners, 18 shopkeepers and 4 traditional healers. The information thus obtained were recorded and then compared. Results showed that the usage of kshirakakoli containing formulations was highest in Himachal Pradesh and Uttrakhand. Only few clinical studies have been done on these formulations. The effectiveness of the formulations against remedies alluded by the trado-medical practitioners claimed was found accurate as per ayurvedic textual literature. Hence, the ethno medicinal survey provides a precise guidance to scientists for future research on these kshirakakoli containing formulations that are useful in plethora of disorders.


Ethnomedicinal survey; Kshirakakoli; Formulations; Ayurveda; Fritillaria roylei

Full Text:



Anesini, C., Perez, C. (1993). Screening of plants used in Argentine folk medicine for antimicrobial activity. Journal of ethnopharmacology, 39(2) 119-128. 10.1016/0378-8741 (93) 90027-3.

Chatterjee, A., Dhara, K.P., Pascard, C., Prange, T. (1976). Kashmirine, a new steroidal alkaloid from Fritillaria roylei, Hook (Liliaceae). Tetrahedron Lett., 33 2903-2904.

Chi, Y.F., Kao, Y.S., Chang, K.J. (1940). The Alkaloids of Fritilaria Roylei. II. Isolation of Peiminine1. Journal of the American Chemical Society, 62(11) 2896-2897. DOI:

Chou, T.Q. (1947). Some minor alkaloids of pei‐mu, Fritillaria roylei. J. Am. Pharma. Assoc., 36(7) 215-217. DOI:

Dhyani, A., Nautiyal, B.P., Nautiyal, M.C. (2010). Importance of Astavarga plants in traditional systems of medicine in Garhwal, Indian Himalaya. Int. J. Biodiv. Sc., Ecosystem Services & Management, 6(1-2)13-19. DOI: 21513732 .2010.521490.

Girish, K.J. (2017). Clinical Study on Effectiveness of Shukra-Shodhana-Janana Granules and Erandmula Kvatha in Patients of Oligospermia. Journal of Ayurveda Physicians & Surgeons, 4(3) 35-38. ISSN 2394- 6350

Hebbar, J.V. (2016b). Charaka Samhita Chikitsa Sthana; Vatavyadhi Chikitsa Adhyaya: Chapter 28, 2016b. [Date last accessed 03 March 2018].

Hebbar, J.V. (1998). Charak Samhita, Chaukhambha Orientalia Varanasi, Volume II, Section 6 Chikitsasthanam, Chapter II, Qtr 3 (2.3), Shloka 15-17 45.

Hebbar, J.V. (2015a). Charak Samhita Sutrasthana; Mashaparna Bhrutiya Adhyaya Charaka Chikitsa 2.3, [Date last accessed 03 March 2018].

Hebbar, J.V. (2015b). Charaka Samhita Chikitsa; Charaka Kshatasheena Chikitsa: Chapter 11, 2015b. [Date last accessed 03 March 2018].

Hebbar, J.V. (2015c). Charaka Chikitsa; Trimarmeeya Chikitsa: Chapter 26, http://www. /2015/12/22/ trimarmeeya-chikitsa-charaka-26/ 2015c. [Date last accessed 03 March 2018].

Hebbar, J.V. (2016a). Charaka Samhita Chikitsa Sthana; Charaka Samhita Vatarakta Chikitsa: Chapter 29, /2016/01/06/ charaka-vatarakta-chikitsa-29/ 2016a. [Date last accessed 03 March 2018].

Hebbar, J.V. (2016c). Charaka Samhita Sutrasthana Asikta Kshiriya Vajikarana Pada: Charak Chikitsa 2.2, [Date last accessed 03 March 2018].

Jiang, Y., Li, P., L,i H.J., Yu, H. (2006). New steroidal alkaloids from the bulbs of Fritillaria puqiensis. Steroids, 71(9) 843-848. DOI: 10.1016/j. steroids. 2006.05.016

Kaur, G., Gupta, V., Kumar, S., Singhal, R.G., Maithani, M., Bansal, P. (2019). Compliance level of textual therapeutic usage of kakoli-containing formulations with ethnomedicinal survey and modern system of medicine. Imam Journal of Applied Sciences, 4(2) 62-68. DOI: 10.4103/ijas.ijas_1_19.

Kaushik, R., Sharma, P., Prakash, O. (2017). Management of Cervical Spondylosis through Ayurveda: A Case Study. Int. J. Res. Ayu. Pharm. 8(2) 179-181. DOI:

Kshiti, S. (2012). Introduction of Ayurveda and Human Potential: The First Life Science. Journal of Phytopharmacology, 1(2) 1-5. ISSN: 2320-480X

Kunjibettu, S., Chaudhari, K., Dei, L. (2017). Role of Uttarabasti in the Management of Female Infertility-Evidence Based Critical Review. J. Ayu. & Holistic Med., 5(1) 1-12. ISSN-2321-1563

Lekurwalel, P.S., Pandey, K., Yadaiah, P. (2010). Management of Amavata with ‘Amrita Ghrita’: A clinical study. AYU, 31(4) 430-435. DOI: 10.4103/0974-8520. 82033.

Panda, A.K., Debnath, S.K. (2011). Effectiveness of Kativasthi and excersice in chronic low back pain: A Randomized control study. Int. J. Resh. Ayu. Pharm. 2(2) 338-342.

Patel, J. (2018). Clinical Efficacy of Bala Taila Uttarbasti the Management of Urethral Stricture: Case Report. Int. J. Curr. Resh. 10(8) 73068-73071. DOI: /10.24941/ ijcr.32201.08.2018.

Pawar, S.D., Gaidhani, S.N., Anandan, T. (2011). Evaluation of Anti Inflammatory, Analgesic and Anti-Arthritic Activity of Mahanarayana Tailam in Laboratory Animals. Adv. Pharmacol. Toxicol., 12(3) 33-42. ISSN - 0973-2381

Pusuluri, Y.V.S.M.K., Wasedar, V.S., Dani, H. (2017). Effect of punarnavadi Mandoor and Shiva Gutika in Acute Deep Vein Thrombosis- A Case Report. J. Ayu. Integ. Med. Sci., 2(4) 296-298. DOI:

Rathod, M., Mutha, R., Murgesh, S., Sharma, A., Acharya, G.S., Sharma, A.K. (2013). Clinical Study to Evaluate the Therapeutic Effect of Shivagutika in Patients with H.I.V. Int. Ayu. Med. J. 1(3) 1-7. ISSN:2320- 5091

Sagar, P.K. (2014). Adulteration and substitution in endangered, ASU herbal medicinal plants of India, their legal status, scientific screening of active phytochemical constituents. Int. J. Pharm. Sci. Res., 5(9) 4023-4039. DOI: 10.13040/IJPSR.0975-8232.5 (9).4023-4039.

Saha, D., Ved, D., Ravikumar, K., Haridasan, K., Dhyani, A. (2015). Lilium polyphyllum. The IUCN Red List of Threatened Species, 2015. Available at: [Date last accessed 25, Nov, 2019].

Sharma, B.D., Balkrishna, A.V. (2005). Vitality strengthening Astavarga plants (Jeevaniya & Vayasthapan Paudhe), Divya Publishers, Uttaranchal (India).

Sharma, P., Nariyal, V., Sharma, S., Sharma, A. (2017). Reproductive and Child Health Care through Bala Taila: A Review on Ayurveda Formulation. Int. J. Res. Ayurveda Pharm. 8(3) 1-4. DOI:

Shripathi, A.H., Malagi, K.J., Hebbar, K.R. (2017). Evaluating the Importance of Bahya and Abhyantara Prayoga of Mushika Taila in Complete Rectal Prolapse: A Case Study. Int. J. Ayu. Pharm. Chem. 7(2) 120-128. ISSN 2350-0204.

Shukla, V. J., Poonam Manjusha, R., Vaghela, D. B. (2011). A clinical study on the role of Akshi Tarpana with Jeevantyadi Ghrita in Timira (Myopia). AYU, 32(4) 540-545. DOI:

Tewari, N.N. (1991). Some crude drugs: source, substitute and adulterant with special reference to KTM crude drug market. Sachitra Ayurved, 44(4) 284-290.

Vanishree, S.K., Kumari, C.A. (2017). Treating Post Salphyngectomy Infertility with Ayurveda- A Case Study. World J. of Pharmacy and Pharmaceutical Sci., 6(12) 1445-1453. DOI:

Vartak, R.V., Mehere, S. (2019). Effect of ashoka ghrita in asrigdhar (menorrhagia): A case study. Ayur log: National J. Research in Ayurved Science, 3(2) 1-5. ISSN: 2320-7379

Vinaik, A., Kataria, A., Singhal, H.K., Kumar, K. (2013). A Clinical Study on Jeevaniya Ghrita and Drishti Prasadaka Yoga (Formulated Compound) in the Management of Computer Vision Syndrome (CVS) w.s.r Shushkakshipaka. Int. Ayurvedic Medical Journal, 1(6) 154-162. DOI:

Wasedar, V.S., Kapoor, T., Rao, N. (2017). Chronic Liver Disease Management in Ayurveda W.S.R. to Garavisha (Artificial Poison) – A Case Report. Int. Ayu. Med. J. 1(3) 364-368. ISSN: 2320- 5091

Wu, Y.H. (1944). The Constituents of Fritillaria roylei. J. Am. Chem. Soc., 66(10) 1778-1780. DOI:



  • There are currently no refbacks.

Copyright (c) 2021 Gunpreet Kaur, Vikas Gupta, Ravinder Sharma, Sanjiv Kumar, R G Singhal, Ranjit Singh, Parveen Bansal

Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

Creative Commons License
This work is licensed under a CC BY-NC