Email this article 
Analysis of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) Levels in Rats Given Jamu Cekok Decoction
Abstract
Jamu cekok is a traditional medicine used by Indonesians, especially children to increase appetite. However, the safety test of jamu cekok on liver function using Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) as parameters has never been evaluated. This study aimed to determine the effect of jamu cekok on liver function by assessing SGOT and SGPT levels in rats subjected to acute toxicity. The study employed an analytical experimental design with the OECD 425 method. The test rats used were 12, divided into a control group, a 2000 mg/kg BW treatment group and a 5000 mg/kg BW treatment group. The treatment of jamu cekok decoction was given once on the first day of the acute toxicity test and was observed for 14 days. SGOT and SGPT levels were measured and analyzed using one-way ANOVA to assess differences between groups. Through this study, observations of behavior and body weight over the 14 days showed no signs of toxicity or mortality. The LD50 value was determined to be greater than 5000 mg/kg BW, which is categorized as practically non-toxic. One-way ANOVA followed by Tukey’s HSD post hoc tests revealed no significant differences in SGOT levels between the control and treatment groups (p>0,05). Similarly, SGPT levels also showed no significant difference (p>0,05) between groups. These findings indicate that he administration of jamu cekok at a dose of 2000 mg/kg BW and 5000 mg/kg BW does not induce toxic effects on liver function, as reflected by SGOT and SGPT measurements.
Keywords
Full Text:
PDFReferences
Arief, H., Aris, M., & Wijaya, U. (n.d.). Peranan Stres Oksidatif Pada Proses Penyembuhan Luka. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 5.
Astuti, N. (2019). Uji Toksisitas Akut Isolat Etil P-Metoksisinamat Kencur (Kaempferia Galanga L.) pada Mencit Swiss Webster Betina Menggunakan Metode Standar OECD 425 Up and Down Procedure.
Ayun, A. Q., Faridah, D. N., Yuliana, N. D., & Andriyanto, A. (2021). Pengujian Toksisitas Akut LD50 Infusa Benalu Teh (Scurrula sp.) dengan Menggunakan Mencit (Mus musculus). Acta Veterinarta Indonesiana, 9(1), 53–63.
https://doi.org/https://doi.org/10.29244/avi.9.1.53-63
BPOM RI. (2023). Pedoman Penyiapan Bahan Baku Obat Bahan Alam Berbasis Ekstrak/Fraksi (1st ed.). Badan Pengawas Obat Dan Makanan Republik Indonesia.
Erinda, T. W. (2012). Pengaruh Ekstrak Jahe (Zingiber Officinale Rosc.) Var. Gajah Terhadap Kualitas Spermatozoa Mencit (Mus Musculus) yang Terpapar 2-Methoxyethano. Universitas Airlangga.
Erindyah, R. W., Arifah, S. W., Tri, B. J., Nastity, Z. A. P., & Devi, D. A. (2024). Uji Efektivitas Antihiperurisemia Ekstrak Etanol Kencur (Kaempferia Galanga L.) Dan Jahe Hitam (Kaempferia Parviflora) Terhadap Tikus Yang Diinduksi Jus Hati Ayam Dan Potassium Oxonat. Journal Of Pharmaceutical And Sciences, 7(3), 348–357.
Fadila, R. I., Iqbal, M., Triyandi, R., & Rahayu, I. D. (2024). Analisis Aktivitas Antioksidan Pada Temulawak (Curcuma xanthorrhiza Roxb.) dan Jahe Merah (Zingiber officinale var Rubrum). Medula, 14(4), 719–724.
Handajani, S. R., & Widhiastuti, K. E. (2018). Pengaruh Jamu Cekok terhadap Kenaikan Berat Badan dan Jumlah Makanan yang Dikonsumsi Mencit. Jurnal Kebidanan Dan Kesehatan Tradisional, 3(2).
Lely, Y. Q. N., Sulistyani, E., & Yuwono, B. (2016). Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) pada Tikus Wistar (Rattus norvegicus) Jantan yang Dipapar Stresor Rasa Sakit Electrical Foot Shock selama 28 Hari. E-Jurnal Pustaka Kesehatan, 4, 73–77.
Limananti, A. I., & Triratnawati, A. (2010). Jamu Cekok Components for Treating Children Have No Appetite: An Ethnomedicine Approach . Makara Journal of Health Research, 7(1), 11–20. https://doi.org/10.7454/msk.v7i1.136
Lukito, P. K., Indriani, R., Andayani, D., Pujiati, S., & Hayati, K. (2022). Panduan Penyusunan Protokol Uji Praklinik Uji Toksisitas Akut. BPOM RI.
Makiyah, A., & Tresnayanti, S. (2017). Uji Toksisitas Akut yang Diukur dengan Penentuan LD50 Ekstrak Etanol Umbi Iles-Iles (Amorphophallus variabilis Bl.) pada Tikus Putih Strain Wistar. Bandung Medical Journal, 49(3), 145–155.
Marni, M., & Ambarwati, R. (2015). Khasiat Jamu Cekok Terhadap Peningkatan Berat Badan Pada Anak. Jurnal Kesehatan Masyarakat, 11(1), 102.
https://doi.org/10.15294/kemas.v11i1.3522
Nuari, D. A., Sadino, A., & Ainaya, S. H. (2023). The Safety Evaluation of Some Plants of the Zingibereceae Family. Buletin Farmatera, 8(1).
Nurmala, S. (2017). Uji Toksisitas Akut Senyawa Etil p-Metoksisinamat yang Diisolasi dari Rimpang Kencur (Kaempferia galanga L). Fitofarmaka: Jurnal Ilmiah Farmasi, 7(2), 30–33.
Organisation for Economic Co-operation and Development (OECD). (2022). Test No. 425: Acute Oral Toxicity – Up-and-Down Procedure. Internet.
https://www.oecd.org/termsandconditions/
Peraturan BPOM Tentang Pedoman Uji Toksisitas Praklinik Secara In Vivo, Pub. L. No. No. 10 Tahun 2022, Kepala BPOM Republik Indonesia (2022).
Rezki, A. G., Uljanati, K., Aulia, A. H., & Andriani, I. (2024). Systematic Literature Review: Analisis Manfaat Tanaman Kencur (Kaempferia Galanga L.). VISA: Journal Of Visions And Ideas, 4(3), 1763.
Riset, A., Hidayati, A. K., Rijal, K. S., Wello, E. A., Sommeng, F., Julyani, S., & Et al. (n.d.). Pengaruh Kunyit Kuning (Curcuma Longa) Terhadap Gambaran Mikroskopik Hati Tikus (Rattus Norvegicus) Yang Diinduksi Etanol Absolut. Fakumi Medical Journal.
Rosida, A. (2016). Pemeriksaan Laboratorium Penyakit Hati. Berkala Kedokteran, 12, 123–131.
Saraswati, T. R. (2016). Efek Pemberian Serbuk Kunyit Dalam Pakan Terhadap Hepar Puyuh Jepang (Coturnix japonica). Buletin Anatomi Dan Fisiologi, 23(2), 94–100.
https://doi.org/https://doi.org/10.14710/baf.v23i2.10022
Sasmito, W. A., Wijayanti, A. D., Fitriana, I., & Sari, P. W. (2015). Pengujian Toksisitas Akut Obat Herbal Pada Mencit Berdasarkan Organization for Economic Co-operation and Development (OECD). Jurnal Sain Veteriner, 33(2), 234–239.
Widarti, W., & Nurqaidah, N. (2019). Analisis Kadar Serum Glutamic Pyruvic Transaminase (SGPTt) dan Serum Glutamic Oxaloacetic Transaminase (SGOT) pada Petani yang Menggunakan Pestisida. Jurnal Media Analis Kesehatan, 10(1), 35.
Yuneldi, R. F., Saraswati, T. R., & Yuniwarti, E. Y. W. (2018). Profile of SGPT and SGOT in Hyperglycemic Male Rats (Rattus norvegicus) After Administration of Insulin Leaf Extract (Tithonia diversifolia). Biosaintifika: Journal of Biology & Biology Education, 10(3), 519–525.
DOI: https://doi.org/10.14421/biomedich.2026.151.189-198
Refbacks
- There are currently no refbacks.
Copyright (c) 2026 Risya Alfhadillah, Puji Astuti, Sari Rahmayanti, Virhan Novianry
Biology, Medicine, & Natural Product Chemistry |
|
