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| Dublin Core |
PKP Metadata Items |
Metadata for this Document |
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| 1. |
Title |
Title of document |
Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents |
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| 2. |
Creator |
Author's name, affiliation, country |
Cintya Nurul Apsari; Universitas Gadjah Mada; Indonesia |
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| 2. |
Creator |
Author's name, affiliation, country |
Navista Sri Octa Ujiantari; Universitas Gadjah Mada; Indonesia |
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| 2. |
Creator |
Author's name, affiliation, country |
Zuliyati Rohmah; Universitas Gadjah Mada; Indonesia |
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| 2. |
Creator |
Author's name, affiliation, country |
Setyowati Triastuti Utami; Universitas Gadjah Mada; Indonesia |
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| 2. |
Creator |
Author's name, affiliation, country |
Artania Adnin Tri Suma; Universitas Gadjah Mada; Indonesia |
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| 2. |
Creator |
Author's name, affiliation, country |
Niar Gusnaniar; National Research and Innovation Agency (BRIN); Indonesia |
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| 3. |
Subject |
Discipline(s) |
Chemistry; Biology; Medicine; Journal Biology; Medicine Journal |
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| 3. |
Subject |
Keyword(s) |
Anxiety; aroma; fragrances; in silico; VOCs |
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| 4. |
Description |
Abstract |
In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment. |
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| 5. |
Publisher |
Organizing agency, location |
Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity |
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| 6. |
Contributor |
Sponsor(s) |
Universitas Gadjah Mada, Faculty of Pharmacy; Universitas Gadjah Mada, Integrated Laboratory for Research and Testing / Laboratorium Penelitian dan Pengujian Terpadu (LPPT) |
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| 7. |
Date |
(YYYY-MM-DD) |
2024-06-28
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| 8. |
Type |
Status & genre |
Peer-reviewed Article |
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| 8. |
Type |
Type |
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| 9. |
Format |
File format |
PDF |
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| 10. |
Identifier |
Uniform Resource Identifier |
https://sciencebiology.org/index.php/BIOMEDICH/article/view/536 |
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| 10. |
Identifier |
Digital Object Identifier (DOI) |
https://doi.org/10.14421/biomedich.2024.131.239-250 |
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| 11. |
Source |
Title; vol., no. (year) |
Biology, Medicine, & Natural Product Chemistry; Vol 13, No 1 (2024) |
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| 12. |
Language |
English=en |
en |
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| 13. |
Relation |
Supp. Files |
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| 14. |
Coverage |
Geo-spatial location, chronological period, research sample (gender, age, etc.) |
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| 15. |
Rights |
Copyright and permissions |
Copyright (c) 2024 Cintya Nurul Apsari, Navista Sri Octa Ujiantari, Zuliyati Rohmah, Setyowati Triastuti Utami, Artania Adnin Tri Suma, Niar Gusnaniar
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