Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents

Cintya Nurul Apsari, Navista Sri Octa Ujiantari, Zuliyati Rohmah, Setyowati Triastuti Utami, Artania Adnin Tri Suma, Niar Gusnaniar

Abstract


In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment.

Keywords


Anxiety; aroma; fragrances; in silico; VOCs

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References


[KBBI] Kamus Besar Bahasa Indonesia / Great Dictionary of the Indonesian Language, (online), available at: https://kbbi.web.id/ (accesed on November 8th 2023)

Alqethami, A., Hawkins, J. A., & Teixidor-Toneu, I. (2017). Medicinal plants used by women in Mecca: urban, Muslim and gendered knowledge. Journal of ethnobiology and ethnomedicine, 13, 1-24, doi: http://dx.doi.org/10.1186/s13002­017­0193­4

Api, A. M. (2001). Toxicological profile of diethyl phthalate: a vehicle for fragrance and cosmetic ingredients. Food and Chemical Toxicology, 39(2), 97-108, doi: https://doi.org/10.1016/s0278-6915(00)00124-1

Attique, S. A., Hassan, M., Usman, M., Atif, R. M., Mahboob, S., Al-Ghanim, K. A., Bilal, M., & Nawaz, M. Z. (2019). A molecular docking approach to evaluate the pharmacological properties of natural and synthetic treatment candidates for use against hypertension. International journal of environmental research and public health, 16(6), 923, doi: https://doi.org/10.3390%2Fijerph16060923

Bagherian, H., Ashtiani, F. Z., Fouladitajar, A., & Mohtashamy, M. (2011). Comparisons between conventional, microwave-and ultrasound-assisted methods for extraction of pectin from grapefruit. Chemical engineering and processing: Process Intensification, 50(11-12), 1237-1243, doi: http://dx.doi.org/10.1016/j.cep.2011.08.002

Barkus, C., McHugh, S. B., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P., & Bannerman, D. M. (2010). Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. European journal of pharmacology, 626(1), 49-56, doi: https://doi.org/10.1016/j.ejphar.2009.10.014

Borges e Soares, G. A., Bhattacharya, T., Chakrabarti, T., Tagde, P., & Cavalu, S. (2021). Exploring pharmacological mechanisms of essential oils on the central nervous system. Plants (Basel, Switzerland),11, 1, 21, doi: https://doi.org/10.3390/plants11010021

Chellappa, S. L., & Aeschbach, D. (2022). Sleep and anxiety: From mechanisms to interventions. Sleep medicine reviews, 61, 101583, doi: https://doi.org/10.1016/j.smrv.2021.101583

Cheung, S. C. (2020). The sublime in scent: a comparative study of Japanese Kodo and Chinese incense tradition in the 21st century. Asian Education and Development Studies, 10(1), 95-104, doi: https://doi.org/10.1108/AEDS-02-2020-0035

Coppen, J. J.W. (1995). Flavours and fragrances of plant origin. Food And Agriculture Organization Of The United Nations, Rome.

Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific reports, 7(1), 42717, doi: https://doi.org/10.1038/srep42717

Djordjevic, S. M. (2017). From medicinal plant raw material to herbal remedies. Aromatic and medicinal plants: Back to nature, 25, 269-288, doi: http://dx.doi.org/10.5772/66618

Dudley, E., Yousef, M., Wang, Y., & Griffiths, W. J. (2010). Targeted metabolomics and mass spectrometry. Advances in protein chemistry and structural biology, 80, 45-83, doi: https://doi.org/10.1016/B978-0-12-381264-3.00002-3

Elsayed, Y., Dalibalta, S., Gomes, I., Fernandes, N., & Alqtaishat, F. (2016). Chemical composition and potential health risks of raw Arabian incense (Bakhour). Journal of Saudi Chemical Society, 20(4), 465-473, doi: https://doi.org/10.1016/j.jscs.2014.10.005

Ergin, N. (2014). The fragrance of the divine: Ottoman incense burners and their context. The Art Bulletin, 96(1), 70-97, doi: http://dx.doi.org/10.1080/00043079.2014.877306

Faizal, E. W. S. (2017). Makna Dupa dalam Tradisi Assuro Ammaca di Desa Bone Kecamatan Bajeng Kabupaten Gowa. Skripsi, UIN Alauddin Makassar, 61.

González-Minero, F. J., Bravo-Díaz, L., & Moreno-Toral, E. (2023). Pharmacy and fragrances: Traditional and current use of plants and their extracts. Cosmetics, 10(6), 157, doi: https://doi.org/10.3390/cosmetics10060157

H. Sabbah, A. Bonnamy, D. Papanastassiou, J. Cernicharo, J.-A. Martin-Gago, & C. Joblin. (2017). Identification of PAH Isomeric Structure in Cosmic Dust Analogs: The AROMA Setup. Astrophys. J. 843, doi: https://doi.org/10.3847/1538-4357/aa73dd

Habkirk, S., & Chang, H. (2017). Scents, community, and incense in traditional Chinese religion. Material religion, 13(2), 156-174, doi: http://dx.doi.org/10.1080/17432200.2017.1289306

Hartley, N., & McLachlan, C. S. (2022). Aromas influencing the GABAergic system. Molecules, 27(8), 2414, doi: https://doi.org/10.3390/molecules27082414

Hauger, R. L., Risbrough, V., Oakley, R. H., Olivaresâ€Reyes, J. A., & Dautzenberg, F. M. (2009). Role of CRF receptor signaling in stress vulnerability, anxiety, and depression. Annals of the New York Academy of Sciences, 1179(1), 120-143, doi: https://doi.org/10.1111/j.1749-6632.2009.05011.x

Heisler, L. K., Chu, H. M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998). Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences, 95(25), 15049-15054, doi: https://doi.org/10.1073/pnas.95.25.15049

Islam, M. S., Hossain, R., Ahmed, T., Rahaman, M. M., Al-Khafaji, K., Khan, R. A., ... & Islam, M. T. (2022). Anxiolytic-like effect of quercetin possibly through GABA receptor interaction pathway: In vivo and in silico studies. Molecules, 27(21), 7149, doi: https://doi.org/10.3390/molecules27217149

Jamhari, J. (2001). The meaning interpreted: The concept of Barakah in Ziarah. Studia Islamika, 8(1), doi: http://dx.doi.org/10.15408/sdi.v8i1.696

Karyadi, F. (2022). Membakar Dupa di Masjid: Pandangan Keagamaan Ḥaá¸rat al-Shaykh Muhammad Hasyim Asy’ari dalam Naskah Arab Pegon Pesantren. Manuskripta, 12(1), 147-165, doi: https://doi.org/10.33656/manuskripta.v12i1.204

Kaur, S., & Singh, R. (2017). Role of different neurotransmitters in anxiety: a systemic review. International Journal of Pharmaceutical Sciences and Research, 8(2), 411, doi: https://doi.org/10.13040/IJPSR.0975-8232.8(2).411-21

Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., Zaslavsky, L., Zhang, J., & Bolton, E. E. (2023). PubChem 2023 update. Nucleic Acids Res., 51(D1), D1373–D1380, doi: https://doi.org/10.1093/nar/gkac956

Konyar, D., Hayati, O. K. U. R., & Arslan, Z. (2022). Molecular docking studies of cox inhibitors on wild-type ras. Journal of Faculty of Pharmacy of Ankara University, 46(1), 23-34, doi: https://doi.org/10.33483/jfpau.1008048

Masuo, Y., Satou, T., Takemoto, H., & Koike, K. (2021). Smell and stress response in the brain: review of the connection between chemistry and neuropharmacology. Molecules, 26(9), 2571, doi: https://doi.org/10.3390/molecules26092571

Molecular Operating Environment (MOE), 2022.02 Chemical Computing Group ULC, 910-1010 Sherbrooke St. W., Montreal, QC H3A 2R7, Canada, 2024.

Myers, B., & Greenwood-Van Meerveld, B. (2007). Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity. American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(6), G1622-G1629, doi: https://doi.org/10.1152/ajpgi.00080.2007

Nadilah, W. A. W., Ali, A. M., Mamat, W. N. A. W., & Mahmod, N. H. (2019). Evaluation of DPPH free radical scavenging, α-glucosidase inhibitory, and antimicrobial activities of Aquilaria malaccensis leaf extracts. Journal Of Agrobiotechnology, 10(1), doi: http://dx.doi.org/10.13140/RG.2.2.25987.35368

Nasir, M. A. (2019). Revisiting the Javanese Muslim Slametan: Islam, local tradition, honor and symbolic communication. Al-Jami'ah: Journal of Islamic Studies, 57(2), 329-358, doi: https://doi.org/10.14421/ajis.2019.572.329-358

Nuss, P. (2015). Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatric disease and treatment, 165-175, doi: https://doi.org/10.2147/NDT.S58841

Olivier, B., van Wijngaarden, I., & Soudijn, W. (2000). 5-HT3 receptor antagonists and anxiety; a preclinical and clinical review. European Neuropsychopharmacology, 10(2), 77-95, doi: https://doi.org/10.1016/S0924-977X(99)00065-6

Pavlović, N., Milošević Sopta, N., Mitrović, D., Zaklan, D., Tomas Petrović, A., Stilinović, N., & Vukmirović, S. (2023). Principal Component Analysis (PCA) of Molecular Descriptors for Improving Permeation through the Blood–Brain Barrier of Quercetin Analogues. International Journal of Molecular Sciences, 25(1), 192, doi: https://doi.org/10.3390/ijms25010192

Perkasa, R. D., Dora, N., & Melinda, C. (2020). The suroan tradition of the Javanese migrant community: A case of hessa perlompongan village air batu district asahan regency. Jurnal Ilmu Sosial Mamangan, 9(2), 113-12, doi: https://doi.org/10.22202/mamangan.v9i2.4403

Putri, S. P. (2022). Reog and Its Possession in Preserving Cultural Identity in Central Java, Indonesia. The Proceedings of English Language Teaching, Literature, and Translation (ELTLT), 11, 67-76., doi: https://proceeding.unnes.ac.id/index.php/eltlt/article/view/1673

Rahmanto, B., Halwany, W., Lestari, F., Anwar, K., Triyasmono, L., Rizki, M. I., & Turjaman, M. (2018). Characterization of ethanol extract from agarwood (Aquilaria microcarpa Baill.) Leaf. Jurnal Jamu Indonesia, 3(2), 68-74, doi: https://doi.org/10.29244/jji.v3i2.56

Rashid, M. I., Rashid, H., Andleeb, S., & Ali, A. (2022). Evaluation of blood-brain-barrier permeability, neurotoxicity, and potential cognitive impairment by Pseudomonas aeruginosa's virulence factor pyocyanin. Oxidative Medicine and Cellular Longevity, doi:https://doi.org/10.1155/2022/3060579

Sadgrove, N. J. (2020). Southern Africa as a ‘cradle of incense’in wider African aromatherapy. Scientific African, 9, e00502, doi: https://doi.org/10.1016/j.sciaf.2020.e00502

Sowndhararajan, K., & Kim, S. (2016). Influence of fragrances on human psychophysiological activity: With special reference to human electroencephalographic response. Scientia pharmaceutica, 84(4), 724-752, doi: https://doi.org/10.3390/scipharm84040724

Su, M., Yang, Q., Du, Y., Feng, G., Liu, Z., Li, Y., & Wang, R. (2018). Comparative assessment of scoring functions: the CASF-2016 update. Journal of chemical information and modeling, 59(2), 895-913, doi: https://doi.org/10.1021/acs.jcim.8b00545

The UniProt Consortium. (2023). UniProt: the Universal Protein Knowledgebase in 2023. Nucleic Acids Research, Volume 51, Issue D1, 6 January 2023, Pages D523–D531, https://doi.org/10.1093/nar/gkac1052

UniProt: the universal protein knowledgebase in 2023. Nucleic acids research 51, no. D1 (2023): D523-D531.

Uriu, D., Odom, W., Lai, M. K., Taoka, S., & Inami, M. (2018). SenseCenser: an interactive device for sensing incense smoke & supporting memorialization rituals in Japan. In Proceedings of the 2018 ACM Conference Companion Publication on Designing Interactive Systems (pp. 315-318).

van Calker, D., Biber, K., Domschke, K., & Serchov, T. (2019). The role of adenosine receptors in mood and anxiety disorders. Journal of neurochemistry, 151(1), 11-27, doi: https://doi.org/10.1111/jnc.14841

Vashchinkina, E., Panhelainen, A., Aitta-Aho, T., & Korpi, E. R. (2014). GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area. Frontiers in pharmacology, 5, 256, doi: https://doi.org/10.3389/fphar.2014.00256

Waterhouse, A., Bertoni, M., Bienert, S., Studer, G., Tauriello, G., Gumienny, R., Heer, F.T., de Beer, T.A.P., Rempfer, C., Bordoli, L., Lepore, R., & Schwede, T. (2018) SWISS-MODEL: homology modelling of protein structures and complexes. Nucleic Acids Res, 46, W296-W303, doi:https://doi.org/10.1093%2Fnar%2Fgky427

Wepener, C. (2015). Burning incense for a focus group discussion: Acquiring a spirituality of liminality for doing liturgical research in an African context from an emic perspective. International Journal of Practical Theology, 19(2), 271-291, doi: http://dx.doi.org/10.1515/ijpt-2014-0036

West, A. L., Hoque, N., & Griep, M. H. (2014). Extraction efficacy of synthetic cannabinoids from Damiana leaf substrates utilizing electrolytic solvents. Army research lab aberdeen proving ground md weapons and materials research directorate.

Yadav, V. K., Choudhary, N., Heena Khan, S., Khayal, A., Ravi, R. K., Kumar, P., Modi, S., & Gnanamoorthy, G. (2020). Incense and incense sticks: types, components, origin and their religious beliefs and importance among different religions. J. Bio Innov, 9, 1420-1439, doi: https://doi.org/10.46344/JBINO.2020.v09i06.28

Yagi, S., & Yagi, A. (2021). Important medicinal plants—Sudan, in medicinal and aromatic plants of the world, Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO.

Yuningtyas, L. A., Pranawa, S., & Yuhastina, Y. (2020). The meaning of the Ceprotan tradition in bersih desa for the people of Sekar village. Harmoni Sosial: Jurnal Pendidikan IPS, 7(2), 150-159, doi: http://dx.doi.org/10.21831/hsjpi.v7i2.27978




DOI: https://doi.org/10.14421/biomedich.2024.131.239-250

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Copyright (c) 2024 Cintya Nurul Apsari, Navista Sri Octa Ujiantari, Zuliyati Rohmah, Setyowati Triastuti Utami, Artania Adnin Tri Suma, Niar Gusnaniar



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
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