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Acute Toxicity and Hypoglycemic Effect of a Polyherbal Formulation on Blood Glucose in Oral Glucose Tolerance Test (OGTT) and Alloxan-Induced Diabetic Rats


 
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1. Title Title of document Acute Toxicity and Hypoglycemic Effect of a Polyherbal Formulation on Blood Glucose in Oral Glucose Tolerance Test (OGTT) and Alloxan-Induced Diabetic Rats
 
2. Creator Author's name, affiliation, country Abednego Okeoghene Warri; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, University of Lagos, Lagos; Nigeria
 
2. Creator Author's name, affiliation, country Emuesiri Goodies Moke; Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Delta State University, Abraka; Nigeria
 
2. Creator Author's name, affiliation, country Aishat Oyinkansola Balogun; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, University of Lagos, Lagos; Nigeria
 
2. Creator Author's name, affiliation, country Kennedy Chibogu Nzeh; Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, University of Lagos, Lagos; Nigeria
 
2. Creator Author's name, affiliation, country Emuesiri Kohworho Umukoro; Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Delta State University, Abraka; Nigeria
 
2. Creator Author's name, affiliation, country Earnest Oghenesuvwe Erhirhie; Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Chukwuemeka Odumegwu Ojukwu University, Awka; Nigeria
 
3. Subject Discipline(s)
 
3. Subject Keyword(s) alloxan monohydrate; diabetes mellitus; herbal formulation; LD50 value
 
4. Description Abstract

Madam F. Kayes Bitters® is an herbal formulation commonly used in Nigeria and some African countries in the management of diabetes mellitus and other diseases conditions. This study evaluated the in-vivo hypoglycaemic activity, as well as acute toxicity of the polyherbal formulation to provide its efficacy and safety. Healthy albino mice (20-30 g) and Sprague Dawley female rats (90-130 g) were used for this study. Acute toxicity study (LD50) of the herbal formulation was determined by methods originally described by Miller and Tainter in 1994. Following oral dosing with glucose (2 g/kg) in normal fasted animals, herbal formulation (HF) at various doses was administered and blood glucose levels at 30 minutes, 60 minutes, 90 minutes, and 120 minutes were taken and recorded. Diabetes was induced using alloxan 150 mg/kg and diabetic rats were given the HF at doses of 50, 100, and 200 mg/kg with glibenclamide 2.5 mg/kg used as standard drug treatment. Blood glucose level was determined on 1st day, 7th day, 14th and 21st day. The LD50 was greater than 5g/kg with oral administration. The oral glucose tolerance test showed that the group that received 100 mg/kg HF showed a significant reduction (p<0.05) in glucose level after 120 minutes when compared to the basal level of glucose recorded. All treated diabetic groups showed a significant decrease in glucose level on the 21st day. The herbal formulation of Hydrastis canadesis Aloe capensis, Echinacea angustifolia and honey exhibited a significant glucose-lowering activity in alloxan-induced diabetic rats.
 
5. Publisher Organizing agency, location Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity
 
6. Contributor Sponsor(s)
 
7. Date (YYYY-MM-DD) 2021-10-15
 
8. Type Status & genre Peer-reviewed Article
 
8. Type Type
 
9. Format File format PDF
 
10. Identifier Uniform Resource Identifier https://sciencebiology.org/index.php/BIOMEDICH/article/view/162
 
10. Identifier Digital Object Identifier (DOI) https://doi.org/10.14421/biomedich.2021.102.111-115
 
11. Source Title; vol., no. (year) Biology, Medicine, & Natural Product Chemistry; Vol 10, No 2 (2021)
 
12. Language English=en en
 
13. Relation Supp. Files
 
14. Coverage Geo-spatial location, chronological period, research sample (gender, age, etc.)
 
15. Rights Copyright and permissions Copyright (c) 2021 Abednego Okeoghene Warri, Emuesiri Goodies Moke, Aishat Oyinkansola Balogun, Kennedy Chibogu Nzeh, Emuesiri Kohworho Umukoro, Earnest Oghenesuvwe Erhirhie