Correlation of BMP2 with Degree of Osteitisin Primary CRS with and without nasal Polyps

Edi Handoko, David Santoso, Iriana Maharani, Yuyun Yueniwati P.W, Tanti Agustina

Abstract


Chronic rhinosinusitis (CRS) is an inflammation of the nasal mucosa and paranasal sinuses, persisting for over12 weeks. CRS involves a remodeling process and opacification known as osteitis, resulting from type 2 and non-type two inflammation. Osteitis severity is assessed using CT scans and the Global Osteitis Scoring Scale (GOSS). Bone morphogenetic protein-2 (BMP-2) is crucial in osteogenesis and bone remodeling. However, no research has shown a relationship between BMP-2 concentration and osteitis degree, as measured by GOSS, in CRS patients with or without nasal polyps. The objective of this study is to analyze the relationship between BMP-2 concentration and osteitis degree measure with GOSS in primary CRS. A cross-sectional analytic observational study was conducted using primary RSK as the study population. BMP-2 concentration, a marker for bone remodeling, used ELISA. The osteitis of the paranasal sinus walls was assessed with a CT scan and quantified using the GOSS method.  The study included 44 patients, with 8 of them serving as the control group. It was found that BMP-2 concentration (ng/mL) had a linear relationship with the GOSS degree in patients with CRS, showing a correlation of 0.583 (deviation >0.05). Further analysis revealed a significant correlation between BMP-2 concentration and GOSS, with a coefficient of 0.857 (considered very significant, in the range of 0.76-0.99). This strong correlation indicates that as BMP-2 concentration strongly correlates with the occurance of osteitis, which were measured by GOSS. BMP-2, as a marker for osteitis in CRS, shows a significant and linear correlation with the severity degree of osteitis measured by GOSS.

Keywords


BMP-2 Concentration;Chronic Rhinosinusitis;Global Osteitis Scoring Scale;Osteitis;

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DOI: https://doi.org/10.14421/biomedich.2025.141.43-50

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Copyright (c) 2025 Edi Handoko, David Santoso, Iriana Maharani, Yuyun Yueniwati P.W, Tanti Agustina



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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