Antiepileptic Potential of Justicia insularis Leaf Extract in Swiss Mice

Nancy Elkanah, Michael Chuks Nnumolu, Jude Effiom Okokon, Uduak Peter Ise

Abstract


Epilepsy is a prevalent neurological condition characterized by repetitive seizures, necessitating the exploration of efficacious treatments. Justicia insularis, a plant with a historical use in treating convulsions and epilepsy, has garnered attention as a potential antiepileptic agent. This study aimed to investigate the antiepileptic properties of Justicia insularis leaf extract, focusing on generated seizure models in mice. The analysis of variance (ANOVA), specifically one-way ANOVA, was utilized to assess the statistical significance of the data. Seizure models were employed to evaluate the antiepileptic effects of Justicia insularis leaf extract. The p-values obtained from the one-way ANOVA were significant, with values of ap<0.005, bp<0.01, and cp<0.001. These results suggest the statistical significance of the observed effects in the seizure models. This study provides valuable insights into the therapeutic potential of Justicia insularis leaf extract as a treatment for epilepsy. The significant findings underscore the importance of further research into the use of natural medicines for managing epilepsy, potentially offering new avenues for treatment.

Keywords


Justicia insularis; antiepileptic; seizures; convulsion; GABAA receptor; flavonoids;

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References


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DOI: https://doi.org/10.14421/biomedich.2024.131.271-275

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Copyright (c) 2024 Nancy Elkanah, Michael Chuks Nnumolu, Jude Effiom Okokon, Uduak Peter Ise



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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This work is licensed under a CC BY-NC