Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats

Nwakaego Omonigho Ebong, Jude Efiom Okokon, Jesse Idakwoji


Mammea africana Sabine (Guttiferae), a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha-amylase and alpha-glucosidase enzymes in vivo. The stembark extract (30, 60 and 90 mg/kg) of M. africana were investigated in vivo for inhibitory effect on alpha-amylase and alpha-glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The stembark extract caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the stembark extract of M. africana have the potentials to inhibit alpha-amylase and alpha-glucosidase in rats.


alpha-amylase; alpha-glucosidase; hypoglycaemia; Mammea africana

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Biology, Medicine, & Natural Product Chemistry
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