Effects of Red Coconut Tembuluk (Cocos nucifera var. rubescens) Extract on Uric Acid Level Reduction in Mice (Mus musculus)

Sukmawati Sukmawati, Sutrisnawati Sutrisnawati, Manap Trianto, Masrianih Masrianih, Fatmah Dhafir, I Nengah Kundera

Abstract


Increased levels of uric acid in the blood can lead to metabolic disorders such as gouty arthritis, which require effective management. This study aimed to determine the effect of red coconut tembuluk extract (Cocos nucifera var. rubescens) on reducing uric acid levels in mice (Mus musculus). The study employed an experimental research design using a Completely Randomized Design (CRD). A total of 28 mice were used, divided into seven groups with four replications each. The groups consisted of a normal control group (KN), which received food and water ad libitum; a negative control group (K+); a positive control group (K-); and four treatment groups (PI, PII, PIII, and PIV). The negative control group (K+), positive control group (K-), and all treatment groups were induced with lard oil for 14 days to increase uric acid levels. The positive control group (K?) was treated with allopurinol at a dose of 0.026 mg per 20 g body weight. The normal control (KN) and negative control (K+) groups received food and water ad libitum without extract administration. Treatment group PI received 10% red coconut tembuluk extract, PII received 20%, PIII received 40%, and PIV received 80%. The data obtained were analyzed using Analysis of Variance (ANOVA). The results showed that administration of red coconut tembuluk extract significantly reduced uric acid levels in mice induced with lard oil. The most effective concentration in reducing uric acid levels was 80% (PIV), with an average uric acid level of 5.4 mg/dL.

Keywords


Cocos nucifera var. rubescens; Hyperuricemia; Mus musculus; Tembuluk; Uric acid levels

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References


Abdulkadir, W., Papeo, D. R. P., Akuba, J., & Makkulawu, A. (2022). Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus amaryllifolius) Pada Mencit (Mus musculus). Journal Syifa Sciences and Clinical Research, 4(2), 540–547.

Amatucci, A. J., Padnick-Silver, L., LaMoreaux, B., & Bulbin, D. H. (2023). Comparison Between Early-Onset and Common Gout : A Systematic Literature Review. Journal Rheumatology and Therapy, 10(4), 809–823.

Amrullah, A. A., Fatimah, K. S., Nandy, N. P., Septiana, W., Azizah, S. N., Nursalsabila, … Zain, N. S. (2023). Gambaran Asam Urat pada Lansia di Posyandu Melati Kecamatan Cipayung Jakarta Timur. Jurnal Ventilator, 1(2), 162–175.

Anggraini, T. A., Manafe, D. R. T., Nurina, R. L., & Ratu, K. (2024). Perbandingan Efektivitas Pemberian Air Rebusan Biji Ketumbar dan Air Kelapa Muda Terhadap Penurunan Kadar Asam Urat. Candana Medical Journal, 12(1), 1–15.

Choliq, R. I., Brigita, R., & Zahro, S. N. (2025). Perbandingan Antara Febuxostat dan Allopurinol Sebagai Pengobatan Hiperurisemia Pada Penyakit Gagal Ginjal Kronik. Jurnal Farmasi Malahayati, 8(1), 85–93.

Ernis, G., Handayani, D., & Sundaryono, A. (2020). Dampak Pemberian Ekstrak “ Simbagh Utak” (Hydnophytum formicarum) Terhadap Penurunan Kadar Asam Urat Darah pada Mencit (Mus musculus) Jantan Hiperurisemia. Journal of Science Education, 4(2), 94–100.

Fadhla, A., Maulida, & Putra, E. (2023). Hubungan Pengetahuan Masyarakat Dengan Penanganan pada Gejala Peningkatan Kadar Asam Urat di Desa Kaye Lee Kecamatan Ingin Jaya Kabupaten Aceh Besar. Journal Getsempena Health Science Journal, 2(2), 108–117.

Fitri, W. E., & Putra, A. (2021). Review : Peranan Senyawa Flavonoid Dalam Meningkatkan Sistem Imun Di Masa Pandemi Covid-19. Journal Seminar Nasional Syedza Saintika, 61–72.

Irmawati, Pailan, E. T., & Baharuddin, B. (2023). Analisis Faktor Risiko Gout Arthritis. Jurnal Ilmiah Kesehatan Sandi Husada, 12(1), 157–162.

Jannah, S. R. N., Zubaydah, W. O. S., Suryani, Sahumena, M. H., Sanggi, S. M., & Apricella, A. (2024). Formulasi dan Uji Penetrasi Sediaan Gel Transfersom Allopurinol Dengan Metode Sel Difusi Franz. Lansau: Jurnal Ilmu Kefarmasian, 2(2), 134–147.

Jufri, Zamaa, M. S., Sulaima, Hatta, M., & Serliyani. (2023). Hubungan Pengetahuan Dan Pola Makan Dengan Kadar Asam Urat Pada Penderita Gout Artritis Di Kepulauan Selayar. Jurnal Mitra Sehat., 13, 439–449.

Listiana, L., Wahlanto, P., R, S. S., & Ismail, R. (2022). Penetapan Kadar Tanin Dalam Daun Mangkokan (Nothopanax scutellarium merr) Perasan Dan Rebusan Dengan Spektrofotometer UV-Vis. Pharmacy Genius, 1(1), 62–73.

Mulyanto, A., Mujahid, I., & Khasanah, T. U. (2019). Kemampuan Air Kelapa Muda Sebagai Antimikroba Terhadap Bakteri (Escherichia coli) Penyebab Diare. Mediagro, 04(1), 1–40.

Patyawargana, P., & Falah, M. (2021). Pengaruh Rebusan Daun Salam Terhadap Penurunan Kadar Asam Urat Pada Lansia. Healthcare Nursing, 3(1), 47–51.

Rozani, M. A. S., Hamid, H. A. A., Hadzir, N. M., Latif, M. A. M., & Som, A. M. (2024). Virgin Coconut Oil-Based Emulsion And Its Benefits. Malaysian Journal of Analytical Sciences, 28(5), 1087-1101.

Sirisangsawang, R., & Phetyim, N. (2023). Heliyon Optimization of tannin extraction from coconut coir through response surface methodology. Heliyon, 9(2), e13377.

Tanaka, T. (2025). Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth. Journal of Natural Medicines, 79(5), 967–985.

Wikantyasning, E. R., Wahyuni, A. S., Julianti, T. B., Putri, N. Z. A., & Astuti, D. D. (2024). Antihyperuricemic effectiveness test of ethanol extract of kencur (Kaempferia galanga L.) and black ginger (Kaempferia parviflora) on rats induced by chicken liver juice and potassium oxonate Uji efektivitas antihiperurisemia ekstrak. of Pharmaceutical and Sciences, 348–357.

Wulandari, A., & Yulianto, S. (2021). Pelayanan Jamu Pada Ny.S dengan Peningkatan Kadar Asam Urat dalam Darah Tinggi di Penyehat Tradisional (HATRA) R. Klaten. Jurnal Kebidanan dan Kesehatan Tradisional, 5(1), 41–47.

Zulaikhah, S. T. (2019). Health Beneftis of Tender Coconut Water (TCW). Journal of Pharmaceutical Sciences and Research, 10(2).




DOI: https://doi.org/10.14421/biomedich.2026.151.693-698

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Copyright (c) 2026 Sukmawati Sukmawati, Sutrisnawati Sutrisnawati, Manap Trianto, Masrianih Masrianih, Fatmah Dhafir, I Nengah Kundera



Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

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