Mathematical Model of Cervical Cancer Treatment Using Chemotherapy Drug

Murtono Murtono, Meksianis Zadrak Ndii, Sugiyanto Sugiyanto


Cervical cancer is a malignant disease that causes problems in women's health, especially in developing countries such as Indonesia. Cervical cancer cells will develop quickly, uncontrollably, and will continue to divide and then infiltrate the surrounding tissue and continue to spread to connective tissue, blood, and attack important organs and spinal nerves. The aim of the research is to study the mathematical model of cervical cancer by chemotherapy treatment. The results of this study are that cervical cancer treatment using chemotherapy is effective enough to kill abnormal cells such as infected cells, pre-cancerous cells and cancer cells, although there are side effects, namely the killing of normal cells due to chemotherapy drugs.


Cervical cancer; infected cells; infected cells; cancer cells; chemotherapy

Full Text:



Asih, T. S. N., Lenhart, S., Wise, S., Aryati, L., Adi-Kusumo, F., Hardianti, M. S., & Forde, J. (2016). The dynamics of HPV infection and cervical cancer cells. Bulletin of mathematical biology, 78(1), 4-20.

Boice Jr, J. D., Day, N. E., Andersen, A., Brinton, L. A., Brown, R., Choi, N. W., ... & Hakama, M. (1985). Second cancers following radiation treatment for cervical cancer. An international collaboration among cancer registries. Journal of the National Cancer Institute, 74(5), 955-975.

Bosch, F. X., Manos, M. M., Muñoz, N., Sherman, M., Jansen, A. M., Peto, J., ... & Shan, K. V. (1995). Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. JNCI: Journal of the National Cancer Institute, 87(11), 796-802.

de Pillis, L. G., Gu, W., Fister, K. R., Head, T. A., Maples, K., Murugan, A., ... & Yoshida, K. (2007). Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls. Mathematical Biosciences, 209(1), 292-315.

Naganawa, S., Sato, C., Kumada, H., Ishigaki, T., Miura, S., & Takizawa, O. (2005). Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. European radiology, 15(1), 71-78.

Rose, P. G., Bundy, B. N., Watkins, E. B., Thigpen, J. T., Deppe, G., Maiman, M. A., ... & Insalaco, S. (1999). Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. New England Journal of Medicine, 340(15), 1144-1153.

Sari, H. E., Mudigdo, A., & Demartoto, A. (2016). Multilevel Analysis on the Social Determinants of Cervical Cancer in Yogyakarta. Journal of Epidemiology and Public Health, 1(2), 100-107.

Walboomers, J. M., Jacobs, M. V., Manos, M. M., Bosch, F. X., Kummer, J. A., Shah, K. V., ... & Muñoz, N. (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. The Journal of pathology, 189(1), 12-19.

Wuryanti, S., Andrijono, A., Susworo, S., & Witjaksono, F. (2015). The effect of high poly unsaturated fatty acid (PUFA) dietary supplementation on inflammatory status of patients with advanced cervical cancer on radiation treatment. Acta Medica Indonesiana, 47(1).



  • There are currently no refbacks.

Copyright (c) 2019 Murtono Murtono, Meksianis Zadrak Ndii, Sugiyanto Sugiyanto

Biology, Medicine, & Natural Product Chemistry
ISSN 2089-6514 (paper) - ISSN 2540-9328 (online)
Published by Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity.

Creative Commons License
This work is licensed under a CC BY-NC